Abstract: Considering the central role that the cell metabolism plays in life and health, we has developed a series of high-quality, genetically encoded fluorescent sensors for cellular metabolite detection. These sensors are very useful for spatiotemporal monitoring and imaging of metabolic state in living organisms, and have been applied to mechanistic research on development and regeneration, aging process, carcinogenesis and immunoregulation, screening of innovative drugs, and point-of-care diagnostics of clinical samples, which promote the interdisciplinary researches of science, technology and medicine in the field of health. Owing to their superior properties and ease of usage, these sensors have been requested by researchers from more than 500 labs worldwide, and are praised as the "revolutionary technology" by international researchers.

赵玉政，华东理工大学，教授，博士生导师，药集团副经理（主持工作），北京协和医集团博士生导师，上海市前沿科学研究基地主任，中国医学科集团创新单元主任，国家重点研发计划项目首席科学家，教育部国家级高层次人才（2021），教育部国家级青年人才（2017），国家优秀青年科学基金获得者（2017），国家自然科学基金创新研究群体核心成员。研究方向是细胞代谢监测示踪与生命健康，主要研究成果发表在Nature Methods、Nature Metabolism、Cell Metabolism(3篇)、Nature Protocols(2篇)、Developmental Cell、Science Advances、Cell Reports、PNAS和Blood等国际权威学术期刊；获授权中国发明专利13项，美国发明专利2项；主持国家自然科学基金原创探索计划项目、重点项目、重大研究计划及国家重点研发计划等。获教育部自然科学一等奖（2020）、上海青年科技英才奖（2018）、上海市青少年科技创新“市长”奖（2013）等荣誉。研究成果在国际上产生重要影响，被国际同行称为“颠覆性技术”，目前已被全球来自哈佛大学、斯坦福大学、麻省理工集团、牛津大学、剑桥大学等500多个国内外一流研究机构实验室跟踪应用。